乳腺癌干细胞信号转导通路的研究进展

随着乳腺癌干细胞的发现,人们对于乳腺癌的发生、发展、转移等机制有了进一步的了解。Wnt/β-catenin、Notch、Hedgehog 3条信号通路对乳腺干细胞的自我更新与分化起着重要的作用,一旦信号通路发生异常,乳腺干细胞就会异常分化,无限增殖形成乳腺癌干细胞,进而形成乳腺癌。为了更好地了解Wnt/β-catenin、Notch、Hedgehog 3条信号通路在乳腺癌干细胞中的调控机制,以及信号通路关键分子的表达情况,现结合信号通路的研究进展予以简要综述。

The Research Progress of Signal Transduction Pathway in Breast Cancer Stem Cells

With the discovery of breast cancer stem cells,we have further understood complicated mechanisms of the occurrence,development and metastasis of breast cancer.Wnt/β-catenin,Notch,and Hedgehog,the 3 signaling pathways play an important role in self-renewal and differentiation of breast stem cells.Once this mechanism is destroyed,breast stem cells can present abnormal differentiation,proliferate unlimitedly forming breast cancer stem cells,then develop into breast cancer.Here is to make a brief summary on relevant signal transduction pathway in the occurrence and development of breast cancer and key molecules of self-renewal of breast cancer stem cells.