| 白细胞介素17在儿童紫癜性肾炎发病中的作用 |
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| 引用本文： | 刘丽莎,钟天鹰,常勇,戈建军. 白细胞介素17在儿童紫癜性肾炎发病中的作用[J]. 医学综述, 2011, 17(17) |
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| 作者姓名： | 刘丽莎 钟天鹰 常勇 戈建军 |
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| 作者单位： | 南京医科大学附属南京儿童医院检验科,南京,210028 |
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| 摘 要： | 目的探讨紫癜性肾炎(HSPN)患儿血清白细胞介素(IL)17水平及其临床意义。方法选择2008年6月至2010年6月在南京市儿童医院门诊或住院治疗的HSPN患儿40例,同时检测同年龄段正常体检健康儿童30例作为对照。采用双抗体夹心酶联吸附法检测HSPN患儿外周血血清IL-17水平。结果过敏性紫癜肾炎患儿血清IL-17水平高于对照组,且与肾脏早期损伤相关。结论 IL-17参与了儿童HSPN的发病过程。
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| 关 键 词： | 紫癜性肾炎 白细胞介素17 肾损伤 |
Role of Interleukin 17 in Pathogenesis of Henoch-Schonlein Purpura Nephritis in Children |
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| LIU Li-sha,ZHONG Tian-ying,Chang Yong,GE Jian-jun. Role of Interleukin 17 in Pathogenesis of Henoch-Schonlein Purpura Nephritis in Children[J]. Medical Recapitulate, 2011, 17(17) |
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| Authors: | LIU Li-sha ZHONG Tian-ying Chang Yong GE Jian-jun |
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| Abstract: | Objective To study the role of interleukin(IL)-17 in children with Henoch-Schonlein purpura nephritis(HSPN).Methods Peripheral blood samples were collected from 40 children with HSPN and 30 normal controls,who were outpatient or inpatient in Nanjing Children′s Hospital from June 2008 to June 2010.The expression of concent ration of IL-17 in blood serum was tested with ELISA.Results The concent ration of IL-17 were significantly higher in children with HSPN compared with thecontrol groups(P<0.05),and the expression of IL-17 may lead to early kinney injure.Conclusion IL-17 may be involved in the course of HSPN. |
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| Keywords: | Henoch-Schonlein purpura nephritis Interleukin-17 Kidney injure |
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