Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography |
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Authors: | A Spissu S Congia M P Piccardi F Fadda A Mangoni G L Gessa |
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Institution: | (1) Clinica delle Malattie Nervose e Mentali, Università di Cagliari, Via Porcell 4, I-09100 Cagliari, Italy;(2) Istituto di Farmacologia, Università di Cagliari, Via Porcell 4, I-09100 Cagliari, Italy |
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Abstract: | The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequent fractions. On the contrary, no significant difference in 5-HIAA concentrations was found in sequential CSF samples. Tiapride increased the mean HVA concentrations and caused a steeper caudocranial gradient of this metabolite but failed to modify 5-HIAA concentrations. The results suggest that tiapride blocks dopamine (DA) receptors and increases DA synthesis. |
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Keywords: | Tiapride Homovanillic 5-HIAA Cerebrospinal fluid Pneumoencephalography |
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