| Ezrin和CD44v6在胃癌中的表达及其临床意义 |
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| 引用本文： | 刘晔,杨静,李辉,李春宏,高志安. Ezrin和CD44v6在胃癌中的表达及其临床意义[J]. 临床与实验病理学杂志, 2009, 25(2) |
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| 作者姓名： | 刘晔 杨静 李辉 李春宏 高志安 |
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| 作者单位： | 辽宁医学院附属第一医院病理科,锦州,121000;辽宁医学院附属第一医院病理科,锦州,121000;辽宁医学院附属第一医院病理科,锦州,121000;辽宁医学院附属第一医院病理科,锦州,121000;辽宁医学院附属第一医院病理科,锦州,121000 |
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| 摘 要： | 目的 探讨胃癌组织中Ezrin和CD44v6的表达及其临床病理意义.方法 应用免疫组织化学(SP法)检测73例胃腺癌患者组织标本、15例胃不典型增生组织及12例癌旁胃黏膜组织中Ezrin和CD44v6的表达情况.结果 (1)Ezrin 在正常胃黏膜组、胃不典型增生组和胃癌组中的阳性表达率分别为41.7%、53.3%和83.6%.CD44v6在正常胃黏膜组、胃不典型增生组和胃癌组中的阳性表达率分别为25%、40%和82.2%.(2)Ezrin和CD44v6的表达与淋巴结转移密切相关,有淋巴结转移组Ezrin与CD44v6的阳性率均明显高于无淋巴结转移组(P<0.05);在Ezrin和CD44v6同时表达组中,淋巴结转移率为63%(34/54例)高于两者均为阴性组(1/6例,16.7%)(P＜0.05).结论 联合检测Ezrin和CD44v6的表达有助于预测胃癌的恶性程度和转移潜能.
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| 关 键 词： | 胃肿瘤 Ezrin CD44v6 侵袭与转移 免疫组织化学 |
Expression of Ezrin and CD44v6 and their clinical significance in gastric carcinoma |
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| LIU Ye,YANG Jing,LI Hui,LI Chun-hong,GAO Zhi-an. Expression of Ezrin and CD44v6 and their clinical significance in gastric carcinoma[J]. Chinese Journal of Clinical and Experimental Pathology, 2009, 25(2) |
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| Authors: | LIU Ye YANG Jing LI Hui LI Chun-hong GAO Zhi-an |
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| Affiliation: | Department of Pathology;Liaoning Medical University;Jinzhou 121000;China |
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| Abstract: | Purpose To explore the clinical significance of Ezrin and CD44v6 proteins expression in the gastric carcinoma.Methods The expression of Ezrin and CD44v6 proteins was detected by immunohistochemistry in 73 cases of gastric carcinoma,15 cases of gastric epithelial dysplasia and 12 cases of normal gastric tissues.Results (1) The positive rates of Ezrin protein were 41.7%,53.3% and 83.6% in normal gastric tissues,gastric epithelial dysplasia and gastric carcinoma,and that of CD44v6 protein were 25%,40% and 82.2... |
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| Keywords: | Ezrin CD44v6 |
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