| 参麦对氧化损伤的肾小管细胞的代谢影响 |
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| 引用本文： | 万英,罗潮淑,吴劲波. 参麦对氧化损伤的肾小管细胞的代谢影响[J]. 黑龙江医学, 2006, 30(5): 325-326 |
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| 作者姓名： | 万英 罗潮淑 吴劲波 |
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| 作者单位： | 泸州医学院病理生理学教研室,四川,泸州,646000;隆昌县人民医院五官科,四川,内江,642150 |
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| 摘 要： | 目的探讨参麦注射液(SMI)对H2O2导致的肾小管细胞氧化性损伤的有氧代谢的影响。方法建立H2O2致鼠肾小管细胞损伤模型,用组织化学方法显示培养小管细胞琥珀酸脱氢酶(SDH)和乳酸脱氢酶(LDH)。结果参麦注射液和泛醌都具有减轻氧化性损伤肾小管细胞SDH及LDH活性丧失的作用,与模型组比较有显著性差异(P<0.01),且参麦注射液对未损伤的小管细胞有明显的保护作用(P<0.01)。结论参麦注射液对H2O2所致的小管细胞氧化性损伤具有明显的保护作用,能保护有氧代谢关键酶的活性,能提高其有氧代谢功能。
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| 关 键 词： | 病理学 参麦注射液 过氧化氢 肾小管细胞 |
| 文章编号： | 1004-5775(2006)05-0325-02 |
| 收稿时间： | 2006-01-11 |
| 修稿时间： | 2006-01-11 |
Effect of Shenmai Injection on the Aerobic Metabolism of H2O2-induced Renal Tubular Cell Injury |
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| WAN Ying,LUO Chao-shu,WU Jin-bo. Effect of Shenmai Injection on the Aerobic Metabolism of H2O2-induced Renal Tubular Cell Injury[J]. Heilongjiang Medical Journal, 2006, 30(5): 325-326 |
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| Authors: | WAN Ying LUO Chao-shu WU Jin-bo |
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| Affiliation: | The Departmont of Pathology, Luzhou Medical College, Luzhou 646000, China |
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| Abstract: | Objective To investigate the effect of SMI on the aerobic metabolism of the H_2O_2-induced renal tubular cell injury.Methods Establish the model of renal tubular cell injury by H_2O_2,and then SDH and LDH in cultured renal tubularepithelial cell was demonstrated with histochemiatry methlds.Results SMI and coenzyme Q_(10) can not only reduce SDH and LDH activity loss in oxidative damaged renal tubular cell,with distinguished significance(P<0.01) compared with control group,but also pretect renal tubular cells those are not damaged.Conclusion SMI can contribute to renal tubular cell recover after H_2O_2-induced oxidative damage.In this aspect,SMI is superior to coenzyme Q_(10).SMI can improve damaged renal tubular cell aerobic metabolism. |
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| Keywords: | Shenmai Injection H_2O_2(ydrogen peroxide) Renal tubular cell |
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