TUR-Bt联合TVBT加吡柔比星灌注治疗膀胱肿瘤疗效观察

目的:探讨经尿道膀胱肿瘤电切术(TUR-Bt)联合经尿道膀胱肿瘤汽化电切术(TVBT)治疗膀胱肿瘤及术后膀胱内灌注吡柔比星(THP)的方法及疗效。方法:采用TUR-Bt联合TVBT及术后行膀胱内灌注THP治疗膀胱肿瘤。结果:22例膀胱肿瘤均一次切除,1例膀胱穿孔改开放手术;平均手术时间:单发瘤20min,多发瘤50min;术后留置尿管4~6d,术后平均住院7d;THP膀胱灌注每周1次,共8周,以后每月1次,连用8个月;随访3个月~4年,无一例复发。结论:TUR-Bt联合TVBT及术后THP灌注治疗膀胱肿瘤,具有操作简单、出血少、并发症少、复发率低、安全性高等优点,且疗效满意。

Clinical Observation of TU R-Bt and TVBT Combined with Intravesical Instillation of THP for Treatment of Bladder Cancer

Objective:To evaluate the method and effect of transurethral resection of bladder tumor(TUR-Bt) and transurethral vaporization of bladder tumor(TVBT) combined with intravesical instillation of pirarubicin(THP) for treatment of bladder cancer.Methods: The bladder cancer was treated with TUR-Bt and TVBT combined with intravesical instillation of THP after operation.Results: 22 cases were operated successfully first time,only 1 case was treated by partial cystectomy;THP was instilled into bladder,then stayed for 60～120 min.In the following eight weeks,intravesical instillation of THP was administered once a week.After eight weeks,it was done once a month for eight months.Metastases did not found after operation during follow-up of 3 months to 48 months.Conclusion: TUR-Bt,TVBT and THP of intravesical instillation,with simplicity in maneuver,less bleeding and fewer complications,are the safe and effective way in the treatment of bladder cancer.