| 羟氯喹对痛风患者血尿酸及血脂的影响 |
| |
| 引用本文： | 曾惠琼,何丹,方向红,孔卫红,叶志中. 羟氯喹对痛风患者血尿酸及血脂的影响[J]. 疑难病杂志, 2011, 10(6): 428-430. DOI: 10.3969/j.issn.1671-6450.2011.06.011 |
| |
| 作者姓名： | 曾惠琼 何丹 方向红 孔卫红 叶志中 |
| |
| 作者单位： | 1. 广东省深圳市第四人民医院门诊部,518000
2. 深圳市香蜜湖风湿病研究所 |
| |
| 摘 要： | 目的探讨羟氯喹治疗对痛风患者血尿酸(UA)和血脂的影响及其安全性。方法将2009年1月—2010年4月治疗的原发性痛风患者43例随机均分为治疗组和对照组,治疗组25例采用一般治疗+控制尿酸药+羟氯喹治疗,对照组18例采用一般治疗+控制尿酸药+小剂量秋水仙碱治疗,观察期6个月,比较2组血清尿酸和血脂的变化。结果 (1)血UA:2组治疗后3、6个月末较治疗前比较差异有统计学意义(P<0.05或P<0.01),且治疗组尿UA降低较对照组同时点明显(P<0.05或P<0.01)。(2)血脂:治疗组治疗后3、6个月末TC、LDL-C、HDL-C水平较治疗前比较差异有统计学意义(P<0.05或P<0.01),而对照组治疗前后变化不明显(P>0.05);治疗组治疗后3、6个月末TC、LDL-C、HDL-C水平较对照组同时点有显著差异(P<0.05或P<0.01)。急性痛风性关节炎复发次数减少,差异无统计学意义(P>0.05)。结论羟氯喹可减少痛风关节炎的发作次数及降低血尿酸、血脂,具有较好耐受性和安全性。
|
| 关 键 词： | 羟氯喹 代谢 痛风 血尿酸 |
The effect of hydroxychloroquine on serum uric acid in patients with gout |
| |
| ZENG Hui-qiong,HE Dan,FANG Xiang-Hong,et al.. The effect of hydroxychloroquine on serum uric acid in patients with gout[J]. Journal of Difficult and Complicated Cases, 2011, 10(6): 428-430. DOI: 10.3969/j.issn.1671-6450.2011.06.011 |
| |
| Authors: | ZENG Hui-qiong HE Dan FANG Xiang-Hong et al. |
| |
| Affiliation: | ZENG Hui-qiong~,HE Dan,FANG Xiang-Hong,et al. Department of Outpatient,the Forth Hospital of Shenzhen,Shenzhen 518000,China |
| |
| Abstract: | Objective To investigate the effect and safety of hydroxychloroquine(HCQ)on serum uric acid(UA)in gout arthritis.Methods Since January 2009 to April 2010,43 rheumatology clinic patients with primary gout were randomly divided into treatment group(25 cases)and control group(18 cases).The patients in treatment group were applied with the general treatment,control of uric acid drugs and hydroxychloroquine;while the patients in the control group was applied with the general treatment,control of uric acid drugs ... |
| |
| Keywords: | Hydroxychloroquine Metabolism Gout Uric acid |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
