| 线栓法制作大鼠脑缺血模型不同类型神经功能缺损特点的研究 |
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| 引用本文： | 张乾,毛善平,李涛,谭杰. 线栓法制作大鼠脑缺血模型不同类型神经功能缺损特点的研究[J]. 疑难病杂志, 2011, 10(4): 282-284. DOI: 10.3969/j.issn.1671-6450.2011.04.016 |
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| 作者姓名： | 张乾 毛善平 李涛 谭杰 |
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| 作者单位： | 武汉大学人民医院神经内科,430060 |
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| 摘 要： | 目的分析线栓法大脑中动脉阻塞(MCAO)制作大鼠脑缺血模型的类型及不同类型的神经功能缺损情况。方法 150只雄性SD大鼠参照Zea-Longa线栓法造模,术后24 h行MR扫描,根据扫描结果将大鼠分成皮质梗死组(CIG)、皮质下梗死组(SIG)及无梗死组(NIG)3组,分析造模术后1 h及24 h的行为学表现。结果 CIG组与SIG组的神经功能缺损在MCAO1h后均与NIG组有统计学差异(P<0.01),而在24 h后CIG组的神经功能缺陷程度明显大于SIG组(P<0.01),但是SIG组大鼠的神经功能缺陷程度与NIG组无明显统计学差异(P>0.05),而在SIG组中1h后与24h后比较神经功能缺损差异有统计学意义(P<0.01)。结论线栓法MCAO制作大鼠脑缺血模型的不同类型所表现的神经功能缺损特点不一样,皮层下梗死在24h内可自行恢复。
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| 关 键 词： | 大脑中动脉阻塞 脑缺血模型 类型 神经功能缺损 大鼠 |
A study of neurologic impairment in different types of cerebral ischemia in rats model after MCAO |
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| ZHANG Qian,MAO Shan-ping,LI Tao,et al.. A study of neurologic impairment in different types of cerebral ischemia in rats model after MCAO[J]. Journal of Difficult and Complicated Cases, 2011, 10(4): 282-284. DOI: 10.3969/j.issn.1671-6450.2011.04.016 |
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| Authors: | ZHANG Qian MAO Shan-ping LI Tao et al. |
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| Affiliation: | ZHANG Qian,MAO Shan-ping,LI Tao,et al.Department of Neurology,People's Hospital of Wuhan University,Wuhan 430060,China |
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| Abstract: | Objective To study the neurologic impairment of different types of cerebral ischemic in rat model with middle cerebral artery occlusion.Methods According to Zea-Longa method,we established disease model in 150 rats,and MR scan were carried out in each rat 24 hours after the surgery.According to the scan results,rats were divided into three groups,cortex infarction group,subcortical infarction group and non-infarction group.Behavioral perfonnance on the time point of 1 hour and 24 hours after the surgery wer... |
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| Keywords: | Middle cerebral artery occlusion Cerebral ischemia model Types Neurologic function impairment Rats |
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