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Haemostatic and fibrinolytic responses to bone marrow transplantation
Authors:Brown S A  Davies S V  Fegan C  West R  Giddings J  Whittaker J  Burnett A K
Affiliation:Department of Haematology, University Hospital of Wales, Cardiff.
Abstract:Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There were prothrombotic and fibrinolytic responses observed during autograft and allograft BMTs. Thrombin-antithrombin and prothrombin fragment F1+2 levels increased from day -7 to -3 (P<0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respectively. A rise in plasmin-antiplasmin levels occurred between days 4 and 14 (P< 0.0004), from 393 ng/ml on day -7 to a peak of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed.
Keywords:bone marrow transplantation    prothrombotic state    fibrinolysis    protein C
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