Haemostatic and fibrinolytic responses to bone marrow transplantation |
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Authors: | Brown S A Davies S V Fegan C West R Giddings J Whittaker J Burnett A K |
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Affiliation: | Department of Haematology, University Hospital of Wales, Cardiff. |
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Abstract: | Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There were prothrombotic and fibrinolytic responses observed during autograft and allograft BMTs. Thrombin-antithrombin and prothrombin fragment F1+2 levels increased from day -7 to -3 (P<0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respectively. A rise in plasmin-antiplasmin levels occurred between days 4 and 14 (P< 0.0004), from 393 ng/ml on day -7 to a peak of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed. |
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Keywords: | bone marrow transplantation prothrombotic state fibrinolysis protein C |
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