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| HPLC法测定阿司咪唑片含量 | |
| 引用本文： | 孙洪刚,徐骞,杨永田,卢刚,李大岩,陈笑强,张杰,贾首时. HPLC法测定阿司咪唑片含量[J]. 中国药师, 2011, 14(4): 509-511 |
| 作者姓名： | 孙洪刚 徐骞 杨永田 卢刚 李大岩 陈笑强 张杰 贾首时 |
| 作者单位： | 1. 齐齐哈尔市第一医院 黑龙江齐齐哈尔161005 2. 齐齐哈尔医学院药学院 3. 齐齐哈尔市药品检验所 |
| 摘 要： | 目的:建立高效液相色谱法测定阿司咪唑片的含量.方法:色谱柱:Dikma-C18(150 mm ×4.6 mm,5μm)柱；流动相:0.05 mol·L-1磷酸二氢钾溶液-乙晴(65∶35)；流速:1.0 ml·min-1；检测波长:285 nm.结果:阿司咪唑在5.04～100.76 μg·ml-1范围内,与峰面积值呈良好的线性关系,r =0.999 7；平均加样回收率为99.04％,RSD=0.17(n=9).结论:本法专属性强,操作简便,结果准确可靠. |
| 关 键 词： | 阿司咪唑 高效液相色谱法 含量测定 |
Determination of Astemizole Tablets by HPLC |
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| Sun Honggang , Xu Qian , Yang Yongtian , Lu Gang , Li Dayan , Chen Xiaoqiang , Zhang Jie , Jia Shoushi. Determination of Astemizole Tablets by HPLC[J]. China Pharmacist, 2011, 14(4): 509-511 | |
| Authors: | Sun Honggang Xu Qian Yang Yongtian Lu Gang Li Dayan Chen Xiaoqiang Zhang Jie Jia Shoushi |
| Affiliation: | Sun Honggang~1,Xu Qian~1,Yang Yongtian~1,Lu Gang~1,Li Dayan~1,Chen Xiaoqiang~1,Zhang Jie~2,Jia Shoushi~2(1.Qiqihar Municipal First Hospital,Heilongjiang Qiqihar 161005,China,2.School of Pharmacy,Qiqihar Medical University 3.Qiqihar Institute for Drug Control) |
| Abstract: | Objective： To establish a method for determination of astemizole tablets by HPLC. Method： The column was Dikma-C18 （ 150 mm ×4. 6 mm,5μm） column. The mobile phase was composed of 0. 05 mol·L-1 KH2PO4_acetonitrile （65： 35） at a flow rate of 1.0 ml.min-1 with detection wavelength of 285 nm. Result： The linear range of astemizole was 5.04-100. 76μg·ml-1 ,r =0. 999 7. The average recovery was 99.04% with RSD of 0. 17% （n = 9 ）. Conclusion： The method is simple, accurate and suitable for the determination of astemizole tablets. |
| Keywords: | Astemizole HPLC Determination |
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