| 天麻素纳米脂质体的制备及其体外释药特性研究 |
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| 引用本文： | 梅华. 天麻素纳米脂质体的制备及其体外释药特性研究[J]. 中国药师, 2011, 14(4): 480-483 |
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| 作者姓名： | 梅华 |
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| 作者单位： | 上海闵行区中心医院药剂科 上海201100 |
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| 摘 要： | 目的:研制天麻素（GTD）纳米脂质体,提高GTD的脑靶向性。方法:用正交设计筛选GTD纳米脂质体的最优处方,对其质量进行评定,并考察其体外释药特性。结果:GTD最优处方组成为:药脂比为1:20,胆固醇:卵磷脂为3:3,药物浓度为60%（w/w）,水化介质为PBS,pH 6.5。由最优制得的GTD纳米脂质体外形圆整,平均粒径为（77.13±7.60）nm,Zeta电位为（-8.35±0.35）mV（n=3）,平均包封率为（65.22±1.63）%（n=9）。体外释药符合Higuchi方程:Q=-0.201 2+0.412 4t1/2（r=0.980 0）,具有明显的缓释特性。结论:GTD处方组成简单,质量较好,具有缓释性,为进一步体内脑靶向性研究奠定了基础。
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| 关 键 词： | 天麻素 纳米脂质体 制备 体外释药 |
Study on the Preparation and Drug Release in vitro of Gastrodin Nanoliposomes |
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| Mei Hua. Study on the Preparation and Drug Release in vitro of Gastrodin Nanoliposomes[J]. China Pharmacist, 2011, 14(4): 480-483 |
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| Authors: | Mei Hua |
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| Affiliation: | Mei Hua(Department of Pharmacy,Shanghai Minhang District Hospital,Shanghai 201100,China) |
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| Abstract: | Objective:To prepare gastrodin(GTD) nanoliposomes in order to enhance the brain targeting ability of GTD.Method: The orthogonal test was used to screen the optimal formulation of GTD nanoliposomes.The quality of GTD nanoliposomes was evaluated and the drug release in vitro was also studied.Results The optimal formulation of GTD nanoliposomes was as followed:the ratio of drug and lipids was 1:20,the ratio of lecithin and cholesterol was 3:3,the concentration of GTD solution was 60%and the hydration solution ... |
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| Keywords: | Gastrodin Nanoliposomes Preparation Drug release in vitro |
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