| 癫痫敏感大鼠脑内GFAP——免疫反应活性的变化 |
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| 引用本文： | 孙艺平,张万琴.癫痫敏感大鼠脑内GFAP——免疫反应活性的变化[J].中国神经科学杂志,1996,3(2):73-78. |
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| 作者姓名： | 孙艺平 张万琴 |
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| 作者单位： | 大连医科大学生理教研室，美国国立环境卫生研究院 |
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| 摘 要： | 用红藻氨酸（ＫＡ）１０ｍｇ／ｋｇ（ｓ．ｃ）诱发大鼠出现癫病发作一个月后，经免疫细胞化学方法观察大鼠脑内神经胶质原纤维酸性蛋自（ＧＦＡＰ）－免疫反应产物的查化。发现海马的ＣＡ１，ＣＡ２，海马下脚和腹侧海马的海马门都位以及梨状皮层，内嗅皮层，隔区，杏仁核，伏隔核和尾核尾部的ＧＦＡＰ免疫染色阳性明显增强，这一现象可能与动物癫痫发作及发作后，癫痫敏感脑区的神经元损伤有关。
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| 关 键 词： | 癫痫敏感性 红藻氨酸 神经原纤维酸性蛋白（IGFAP） |
THE CHANGES OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP)-IMMUNOREACTIVITY IN THE SEIZURE SENSITIVE RAT BRAIN |
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| SUN Yi-Ping, ZHANG Wang-Qin, HONG Jau-Shyong.THE CHANGES OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP)-IMMUNOREACTIVITY IN THE SEIZURE SENSITIVE RAT BRAIN[J].Neuroscience Bulletin,1996,3(2):73-78. |
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| Authors: | SUN Yi-Ping ZHANG Wang-Qin HONG Jau-Shyong |
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| Abstract: | Seizure episodes were induced by administration of kainic acid (10mg/ kg s.c.) in the Sprague-Dawley rats. One month later, the changes of glial fibrillary acidic protein (G F A P)- immunoreactive elements in the rat brain were examined by using immunocytochemical method. Intensive GFAP-im munostainings were found in CA1, CA2, subiculum and ventral hilus of hippocampal formation as well as related areas including amygdaloid, piriform, entorhinal cortex, septum area, accumbens and caudal part of caudate putamen.This phenomenon may associated with neuronal damage during and after seizure episodes. |
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| Keywords: | seizure susceptibility kainic acid glial fibrillary acidic protein (GFAP) |
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