Clinical utility of selected disease activity markers in patients with systemic lupus erythematosus |
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Authors: | Horák P Scudla V Hermanovó Z Pospisil Z Faltýnek L Budiková M Kusá L |
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Affiliation: | (1) Third Department of Internal Medicine, CZ;(2) Department of Clinical Immunology, CZ;(3) Department of Nuclear Medicine, University Hospital of Olomouc, Olomouc, Czech Republic, CZ |
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Abstract: | The objective of this study was to assess the utility of measurement of thrombomodulin, antinucleosome antibodies, sVCAM-1, sICAM-1, neopterin, fas ligand, IL-10 and sIL-2R in patients with systemic lupus erythematosus (SLE) and to compare them with traditional markers of SLE activity (anti-dsDNA antibodies, C3, C4) and the ECLAM index of disease activity. The measurement was performed over a 6-month period at three consecutive time points after 3 months in each of the 52 patients with SLE. Anti-dsDNA antibodies, thrombomodulin, antinucleosome antibodies, sVCAM-1m sICAM-1, neopterin, fas ligand, IL-10 and sIL-2R were tested by ELISA technique, while C3, C4 components of complement were tested by nephelometry. Fas ligand and IL-10 did not correlate with the ECLAM index. The rest of the markers showed significant correlation with the disease activity index. Thrombomodulin and anti-dsDNA antibodies reflect in the best way the changing trend in disease activity. Antinucleosome antibodies seem to be a promising marker useful in early diagnosis. Soluble VCAM-1, sICAM-1, neopterin and sIL-2R are interesting molecules with a role in disease pathogenesis, but their practical utility is limited. Received: 27 September 2000 / Accepted: 31 March 2001 |
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Keywords: | :Adhesive molecules – Antibodies – Cytokines – Disease activity – Neopterin – Systemic lupus erythematosus – Thrombomodulin |
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