经络三联法治疗寻常型银屑病：多中心随机对照研究

目的:评价经络三联法治疗寻常型银屑病的有效性和安全性.方法:采用随机、阳性药物对照、多中心临床研究,将233例分为三联法组(116例)和药物组(117例).三联法组采用用穴位埋线、耳背刺络、耳压三联法进行治疗,埋线根据皮损部位选局部3～4个穴位,2周治疗1次;耳穴取肺、肝、皮质下、神门、头部及四肢部及皮肤严重部分对称点,耳穴贴压每次取3～5穴.药物组口服迪银片,每次5片,每日2次.两组均治疗6周后比较临床疗效、皮损面积评分、皮损严重程度评分情况及安全性.结果:三联法组愈显率为57.8%,药物组为51.3%,两组疗效差异无统计学意义(P＞0.05);两组治疗后皮损面积评分及皮损严重程度评分均较治疗前明显降低(均P＜0.01),组间比较差异无统计学意义(P＞0.05);三联法组不良反应的发生率明显低于药物组.结论:经络三联法治疗寻常型银屑病是有效和安全的.

Meridian three-combined therapy for treatment of ordinary psoriasis: a multi-center randomized controlled study

BSTRACT Objective To evaluate the effectiveness and safety of the meridian three-combined therapy for treatment of ordinary psoriasis. Methods A multi-central, randomized and positive drug controlled trial was adopted, and 233 cases were divided into an observation group of 116 cases and a control group of 117 cases. The observation group was treated with thread embedding at points, blood-letting puncture on the back of ear and auricular point pressing (I. E. meridian three-combined therapy). For thread embedding, 3-4 local points such ear points as Fei (CO_(14)), Gan (CO_(12)), Pizhixia (AT_4), Shenmen (TF_4), cephalic and symmetric points of severe parts of the limb skin were selected according to the skin lesion position, and the treatment was given once each two weeks. For ear point tapping and pressing ,3-5 points were selected in each session. And the control group was treated with oral administration of Diyin Tablets, 5 tablets each time, twice each day. After treatment of 6 weeks, the clinical therapeutic effects, the score of skin lesion area, the scores for skin lesion severity and safety were compared in the two groups. Results The markedly effective rate was 57. 8% in the observation group and 51.3% in the control group with no significant difference between the two-groups (P>0. 05); after treatment the scores for both the skin lesion area and the skin lesion severity were significantly decreased in the two groups compared with those before treatment (P<0. 01) , and with a significant difference between the two groups (P>0. 05). And the incidence rate of the adverse reaction in the observation group was significantly lower than that in the control group. Conclusion The meridian three-combined therapy is effective and safe for treatment of ordinary psoriasis.