Toll样受体和内分泌代谢性疾病

经典的内分泌腺通过神经系统、激素、细胞因子、生长因子与其他器官进行广泛的联系.Toll样受体(TLRs)在多种内分泌细胞和免疫细胞中表达,其研究日益受到关注.TLRs的持续高度激活可导致相应内分泌代谢性疾病的发生,其中TLR-2和TLR4的缺陷导致小鼠在类似全身炎性反应综合征(SIRS)条件下,发生肾上腺皮质应激应答功能障碍;TLR-3在甲状腺疾病的发病机制中发挥特殊作用.TLRs信号途径的激活伴有特定细胞因子和趋化因子的上调,可导致内分泌腺肿瘤的发生;而在胰岛中表达的TLRs增加了胰岛对病毒感染的易感性.

Toll-like receptors and endocrine and metabolic diseases

Endocrine glands link with other tissues via nervous system, hormone, cytokines and growth factors. The expression of Toll-like receptors (TLRs) has been found in several endocrine and immune cells within endocrine glands. Close attention has been paid on its research. However, excessive activation of these receptors contributes to several endocrine and metabolic diseases. TLR-2 and TLR-4 deficiency results in impaired adrenal corticosterone stress response in mice under systemic inflammatory response syndrome-like conditions(SlRS). TLR-3 plays a specific role in thyroid pathophysiology. Activation of TLRs signaling pathways is associated with upregulation of certain cytokines and chemokines, it may contribute to tumorigene-sis. The expression of TLRs in normal pancreatic islets makes islets sensitive to viral infection.