血液透析患者冠状动脉钙化的危险因素

目的 研究血液透析患者冠状动脉钙化情况,并分析其相关危险因素.方法 选择行血液透析治疗的患者201例,横断面调查所有患者血红蛋白、透析前后血清钙、血清磷、血清钾、尿素氮、肌酐、全段甲状旁腺激素、总蛋白、白蛋白、总胆固醇、甘油三酯、C反应蛋白、血清铁、铁蛋白、总铁结合力和冠状动脉钙化情况,分析冠状动脉钙化相关危险因素.结果 201例血液透析患者中发生冠状动脉钙化137例,总钙化发生率为68.2％.冠状动脉钙化组与无钙化组比较,年龄、性别、高血压、糖尿病、收缩压、脉压差、血钾、血磷、Kt/V及腰臀比差异均有统计学意义(P＜0.05).年龄、透析龄、性别、收缩压、脉压差、血钾、血磷为冠状动脉钙化的独立危险因素(P＜0.05);Kt/V为冠状动脉钙化的独立保护因素(P＜0.05).结论 血液透析患者冠状动脉钙化的发生率偏高;年龄、透析龄、性别、收缩压、脉压差、血钾、血磷为冠状动脉钙化的独立危险因素;Kt/V为冠状动脉钙化的独立保护因素.

Risk factors of coronary artery calcification in hemodialysis patients

Objective To analysis the risk factors of coronary artery calcification in hemodialysis patients.Methods All subjects underwent coronary artery CT scan using Philip's spiral CT and the calcification degree was evaluated by calcification scores.The hemodialysis patients were divided into light,middle,heavy coronary artery calcification and noncoronary artery calcification groups according to the CT scan results.Results There were significant differences in age,sex,duration of hemodialysis,systolic pressure,pulse pressure,blood potassium,serium inorganic phosphorus and Kt/V between light,middle,heavy coronary artery calcification groups and noncoronary artery calcification group.Conclusion The coronary artery calcification of hemodialysis patients has been closely correlated with age,sex,duration of hemodialysis,systolic pressure,pulse pressure,blood potassium,serium inorganic phosphorus and Kt/V.The coronary artery calcification has impact on the survival rates of maintenance hemodialysis patients.