穴位敷贴联合中药足浴治疗慢性疲劳综合征临床研究

目的 评价穴位敷贴联合中药足浴治疗慢性疲劳综合征(chronic fatigue syndrom,CFS)的疗效.方法 将符合入选标准的91例CFS患者,采用随机数字表法分为对照组45例和研究组46例.对照组采用常规疗法配合穴位敷贴治疗,研究组在对照组基础上加用中药足浴.2组均连续治疗30d,随访6个月.采用匹兹堡睡眠质量指数量表(Pittsburgh Sleep Quality Index,PSQI)评价睡眠质量、采用BELL氏慢性疲劳综合征积分表评价对日常生活工作的影响、采用疲劳评定量表(Fatigue Scale-14,FS-14)评价疲劳状态,采用ELISA法检测血清IL-1β、IL-6、IL-2及IFN-λ水平,观察并记录随访期间的复发率,评价临床疗效.结果 研究组总有效率为91.3%(42/46)、对照组为71.1%(32/45),2组比较差异有统计学意义(χ2=6.106,P=0.014).治疗后,研究组PSQI(3.7±0.7)分比(4.8±0.6)分,t=-8.008]、FS-14(6.2±1.5)分比(8.0±1.4)分,t=-6.042]评分低于对照组,BELL氏评分(66.7±12.8)分比(50.6±10.2)分,t=6.621]高于对照组(P<0.01);研究组血清IL-1β(3.28±0.63)pg/ml比(6.86±1.14)pg/ml,t=-18.595]、IL-6(20.03±5.79)pg/ml比(24.85±6.88)pg/ml,t=-3.619]水平低于对照组,IL-2(32.96±6.57)pg/ml比(26.78±6.01)pg/ml,t=4.679]、IFN-λ(36.27±6.71)pg/ml比(25.63±5.89)pg/ml,t=8.032]水平高于对照组(P<0.01).随访6个月,对照组复发率为25.0%(8/32)、研究组为7.1%(3/42),2组比较差异有统计学意义(χ2=4.576,P=0.032).结论 穴位敷贴联合中药足浴可明显改善CFS患者的睡眠质量和疲劳指数,降低血清中炎性细胞因子水平.

Clinical research of acupoint application combined traditional Chinese medicine foot bath for the treatment of chronic fatigue syndrome

Objective To investigate the clinical application of acupoint sticking combined traditional Chinese medicine foot bath for the treatment of chronic fatigue syndrome (CFS). Methods According to the random table method, 91 CFS patients were divided into control group (n=45) and the research group (n=46). The patients in the control group were treated with western medicine and acupoint application, while the patients in the research group were treated with Chinese medicine foot bath on the basis of control group. Two groups of patients were treated for 30 consecutive days. The clinical total effective rate of two groups of patients after treatment was assessed. The Pittsburgh sleep quality index scale (PSQI), BELL's chronic fatigue syndrome integral table and fatigue rating scale (FS-14) were determined respectively before and after treatment, at the same time, the levels of serum interleukin IL-1β, IL-6, IL-2 and interferon IFN-λ were detected respectively before and after treatment. In addition, the adverse reactionincidence and recurrence rate of two groups of patients were observed Results The total effective rate of research group was 91.3% (42/46), whilethe total effective rate of control group was 71.1% (32/45). The difference between two groups was statistically significant(χ 2=6.106,P=0.014).After treatment,the PSQI(3.65 ±0.71 vs.4.77 ±0.62,t=-8.008),FS-14(6.16 ±1.52 vs.8.03 ± 1.43,t=-6.042),IL-1β(3.28 ± 0.63 pg/ml vs.(6.86 ± 1.14)pg/ml,t=-18.595)] and IL-6 (20.03 ± 5.79 pg/ml vs. 24.85 ± 6.88 pg/ml, t=-3.619) of research group were significantly lower than the control group (P<0.05), while the BELL's (66.71 ± 12.79 vs.50.62 ± 10.22,t=-6.621), IL-2 (32.96 ± 6.57 pg/ml vs.26.78 ± 6.01 pg/ml, t=4.679)and IFN-λ(36.27 ± 6.71 pg/ml vs.25.63 ± 5.89 pg/mL,t=8.032)of research group were significantly higher than the control group (P<0.05). No serious adverse reactions occurred during the treatment of both groups. The recurrence rate of control group was 25.0% (8/32), which was significantly higher than the research group of 7.1% (3/42) (χ2=4.576, P=0.032). Conclusions The clinical curative effect of acupoint sticking combined Chinese medicine foot bath on the treatment for CFS is significantly, which can significantly improve the patient's quality of sleep and fatigue index, at the same time improve the serum level of inflammatory factors.