化疗与肿瘤免疫原性细胞死亡

化疗耐药是临床难题,研究发现某些蒽环类化合物和奥沙利铂等化疗药物不仅诱导肿瘤细胞凋亡,而且可以引起免疫原性细胞死亡(ICD),通过诱导肿瘤细胞自噬,释放3类信号:钙网蛋白暴露在细胞表面,刺激树突状细胞(DC)吞噬;三磷酸腺苷释放,招募DC进入肿瘤灶;高迁徙率族蛋白B1促进DC与垂死肿瘤细胞形成稳定结合,诱导机体产生特异性的T细胞抗肿瘤免疫.深入理解化疗诱导的ICD,对于完善化疗方案具有重要意义.

Chemotherapy and tumor immunogenic cell death

Chemotherapy resist is the problem for clinic,and some researches find that chemotherapy with anthracycline and oxaliplatin not only induces the tumor cell apoptosis,but also the celt immunogenic cell death (ICD) by inducing the tumor cell apoptosis and releasing three kinds of signals:exposure of calreticulin on the cell surface to stimulate the dendritic cell (DC) to engulf,and the secretion of adenosine triphosphate to recruit DC to enter into tumor bed,and the release of the high mobility group B1 to promote DC to steadily bind with dying tumor cell to induce specific T cell antitumor immune response.It is with great meaning to promote the chemotherapy protocol by studying the ICD induced by chemotherapy.