| 双氢青蒿素的抗肿瘤作用机制 |
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| 引用本文： | 彭文苗,付红星,余丽芳,饶智国.双氢青蒿素的抗肿瘤作用机制[J].国际肿瘤学杂志,2017,44(6). |
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| 作者姓名： | 彭文苗 付红星 余丽芳 饶智国 |
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| 作者单位： | 广州军区武汉总医院肿瘤科,武汉,430070 |
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| 基金项目： | Natural Science Foundation of Hubei Province of China (2014CFC1049)湖北省自然科学基金 |
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| 摘 要： | 双氢青蒿素是青蒿的活性成分之一,可通过与铁离子形成自由基杀伤肿瘤细胞、诱导细胞凋亡、抗肿瘤血管生成、抑制肿瘤侵袭转移、逆转多药耐药、影响细胞内Ca2浓度、调控细胞周期、调节细胞自噬和免疫系统等方式参与抗肿瘤过程,是潜在可利用的抗肿瘤新药.
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| 关 键 词： | 青蒿素类 肿瘤 细胞凋亡 细胞增殖 双氢青蒿素 |
Mechanism of anti-tumor effect of dihydroartemisinin |
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| Peng Wenmiao,Fu Hongxing,Yu Lifang,Rao Zhiguo.Mechanism of anti-tumor effect of dihydroartemisinin[J].Journal of International Oncology,2017,44(6). |
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| Authors: | Peng Wenmiao Fu Hongxing Yu Lifang Rao Zhiguo |
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| Abstract: | Dihydroartemisinin (DHA),the major active metabolite of artemisinin,participates in tumor progression through the following ways:forming free radicals to induce cancer cells death dependent on iron,inducing apoptosis,inhibiting angiogenesis,tumor cells invasion and metastasis,modulating muhidrug resistance,controlling intracellular Ca2+ concentration,regulating cell cycles,cell autophagy and the immune system and so on.Generally,it is considered to be a potential anti-tumor drug. |
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| Keywords: | Artemisinins Neoplasms Apoptosis Cell proliferation Dihydroartemisinin |
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