SOX家族在脑胶质瘤中的表达及作用

脑胶质瘤是神经系统常见的恶性肿瘤.SOX家族的许多基因与脑胶质瘤的发生发展密切相关,其中SOX2、SOX4、SOX7、SOX9基因在脑胶质瘤中均有异常表达.SOX2基因在脑胶质瘤组织中高表达,与脑胶质瘤的恶性分级呈正相关,并且与众多因子协调促进脑胶质瘤的发生、发展;SOX4基因在脑胶质瘤中既是致癌基因又是抑癌基因,且能对多种因子进行调控;SOX7作为一种肿瘤抑制基因,在脑胶质瘤组织中低表达,通过调节相关因子及信号通路抑制脑胶质瘤的发生;SOX9基因在脑胶质瘤组织中高表达,与多种因子协调促进脑胶质瘤的发生及转移,是判断脑胶质瘤患者预后的重要因素.

Expressions and roles of SOX families in glioma

Glioma is a common malignant tumor of nervous system.Many genes of SOX family are closely related to the genesis and development of glioma,among which SOX2,SOX4,SOX7,SOX9 gene are all abnormal in glioma.SOX2 gene is highly expressed in glioma and has positive correlation with the malignant grade of glioma.SOX2 gene coordinates with many factors and promotes the genesis and development of glioma.SOX4 gene plays as both a oncogene and a tumor suppressor gene in brain glioma,and can regulate a variety of factors.SOX7,as a tumor suppressor gene,shows low expression in glioma,and suppresses the genesis of brain glioma by regulating the related factors and signaling pathways.SOX9 gene is highly expressed in glioma tissues,and promotes tumorigenesis and metastasis of glioma by coordinating with a variety of factors,and can be used as an important risk factor for the prognosis of glioma patients.