| CXCL5/CXCR2生物轴在胰腺癌中的研究进展 |
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| 引用本文： | 黄帆,景鸿恩. CXCL5/CXCR2生物轴在胰腺癌中的研究进展[J]. 国际肿瘤学杂志, 2017, 44(2). DOI: 10.3760/cma.j.issn.1673-422X.2017.02.019 |
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| 作者姓名： | 黄帆 景鸿恩 |
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| 作者单位： | 青海大学附属医院肝胆胰一科, 西宁,810000 |
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| 摘 要： | 胰腺癌的增殖、进展、转移是一个多因素参与的过程.其中,CXC类趋化因子配体5(CXCL5)能够识别并结合CXC类趋化因子受体2(CXCR2),通过细胞自分泌或旁分泌等途径激活或调节信号通路的表达.CXCL5/CXCR2生物轴能够在胰腺癌细胞的增殖、黏附、侵袭、转移和预后中发挥作用,并且与胰腺癌血管及淋巴管生成等相关.直接或间接调控CXCL5/CXCR2在胰腺癌中的表达,有望成为靶向治疗胰腺癌的有效手段.
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| 关 键 词： | 胰腺肿瘤 趋化因子CXCL5 受体,白细胞介素8B |
CXCL5/CXCR2 biological axis in pancreatic cancer |
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| Huang Fan,Jing Hongen. CXCL5/CXCR2 biological axis in pancreatic cancer[J]. Journal of International Oncology, 2017, 44(2). DOI: 10.3760/cma.j.issn.1673-422X.2017.02.019 |
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| Authors: | Huang Fan Jing Hongen |
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| Abstract: | The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer. |
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| Keywords: | Pancreatic neoplasms Chemokine CXCL5 Receptor,interleukin-8B |
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