| VEGF和VEGFR通路抑制剂在晚期胃癌治疗中的疗效 |
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| 引用本文： | 李毛吉,姜雷,关泉林. VEGF和VEGFR通路抑制剂在晚期胃癌治疗中的疗效[J]. 国际肿瘤学杂志, 2017, 44(5). DOI: 10.3760/cma.j.issn.1673-422X.2017.05.018 |
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| 作者姓名： | 李毛吉 姜雷 关泉林 |
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| 作者单位： | 1. 730000,兰州大学第一医院肿瘤内科;2. 730000,兰州大学第一医院肿瘤外科 |
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| 基金项目： | 甘肃省科技支撑项目，甘肃省卫生行业科研计划，Science and Technology Support Project of Gansu Province of China，Health Industry Science Foundation of Gansu Province of China |
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| 摘 要： | 抗新生血管形成是目前胃癌治疗的重要研究方向,血管内皮生长因子(VEGF)及血管内皮生长因子受体(VEGFR)抑制剂是主要的研究热点.目前治疗晚期胃癌的VEGF及VEGFR通路抑制剂包括贝伐珠单抗、雷莫芦单抗、阿帕替尼、瑞戈非尼、索拉非尼等,这些药物为晚期胃癌的治疗提供了更多可能性.
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| 关 键 词： | 血管内皮生长因子类 受体,血管内皮生长因子 胃肿瘤 |
Efficacy of VEGF and VEGFR pathway inhibitors in the treatment of advanced gastric cancer |
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| Li Maoji,Jiang Lei,Guan Quanlin. Efficacy of VEGF and VEGFR pathway inhibitors in the treatment of advanced gastric cancer[J]. Journal of International Oncology, 2017, 44(5). DOI: 10.3760/cma.j.issn.1673-422X.2017.05.018 |
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| Authors: | Li Maoji Jiang Lei Guan Quanlin |
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| Abstract: | Anti-neovascularization is an important research direction in the current treatment of gastric cancer.The inhibitors of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) are main research focus.At present,the inhibitors of the pathways of VEGF and VEGFR in the treatment of advanced gastric cancer include bevacizumab,ramucirumab,apatinib,regorafenib,sorafenib,et al.These drugs provide more possibilities for the treatment of advanced gastric cancer. |
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| Keywords: | Vascular endothelial growth factors Receptors,vascular endothelial growth factor Stomach neoplasms |
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