162例局部晚期未手术老年肺鳞状细胞癌患者预后因素分析

目的 对局部晚期未手术老年肺鳞状细胞癌患者进行回顾性分析,确定影响预后的因素.方法 按纳入标准搜集2010年1月1日至2015年1月1日就诊于山西省肿瘤医院的未手术、局部晚期老年肺鳞状细胞癌患者162例.对相关预后因素分别进行Kaplan-Meier单因素和Cox回归多因素分析.结果 162例患者中位年龄73.6岁,总体中位生存期为19.4个月,1年生存率为71.0％,2年生存率为35.9％.Kaplan-Meier单因素分析示:年龄(x2=7.94,P=0.005)、美国东部肿瘤协作组(ECOG)评分(x2=42.12,P=0.000)、放化疗联合与否(x2=14.99,P=0.000)是影响生存的预后因素.Cox回归多因素分析示:ECOG评分(HR=0.30,95％ CI为0.19 ～0.46,P=0.000)、N分期(HR =0.65,95％CI为0.44 ～0.95,P =0.026)是影响预后的独立因素.结论 ECOG评分和N分期是影响未手术、局部晚期老年肺鳞状细胞癌患者生存期的独立预后因素.

Analysis of prognostic factors in 162 elderly patients with inoperable locally advanced squamous cell lung cancer

Objective To retrospectively analyze the elderly patients with inoperable locally advanced squamous cell lung cancer,and determine prognostic factors.Methods According to eligibility criterion,162 cases of elderly patients with inoperable locally advanced squamous cell lung cancer were selected from January 1,2010 to January 1,2015 in Shanxi Tumor Hospital.Related prognostic factors were carried on univariate and multivariate analysis with Kaplan-Meier approach and Cox regression,respectively.Results The median age of 162 patients was 73.6 years old.The overall median survival time was 19.4 months.The 1-year survival rate was 71.0％,and the 2-year survival rate was 35.9％.In univariate analysis with Kaplan-Meier analysis method:age (x2 =7.94,P =0.005),Eastern Cooperative Oncology Group (ECOG) score (x2 =42.12,P =0.000),chemotherapy combined with radiotherapy or not (x2 =14.99,P =0.000) were prognostic factors that influenced survival.Cox regression analysis showed that ECOG score (HR =0.30,95％ CI:0.19-0.46,P =0.000) and N stage (HR =0.65,95％ CI:0.44-0.95,P =0.026) were independent prognostic factors.Conclusion ECOG score and N stage are independent prognostic factors of the elderly patients with inoperable locally advanced squamous cell lung cancer.