| HGF/c-MET信号通路抑制剂在抗胰腺癌中的研究进展 |
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| 引用本文： | 乔银标,杨波.HGF/c-MET信号通路抑制剂在抗胰腺癌中的研究进展[J].国际肿瘤学杂志,2017,44(4). |
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| 作者姓名： | 乔银标 杨波 |
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| 作者单位： | 苏州大学附属第三医院肝胆外科, 常州,213003 |
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| 摘 要： | 胰腺癌是恶性程度较高的肿瘤之一.靶向治疗日渐成为胰腺癌治疗的重要组成部分.研究证实肝细胞生长因子及其受体(HGF/c-MET)信号通路在胰腺癌发生、发展过程中起重要作用,通过抑制该条信号通路能够起到显著的抗胰腺癌作用.因此,HGF/c-MET靶向抑制剂的研究为胰腺癌的治疗开辟了一条新的途径.
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| 关 键 词： | 肝细胞生长因子 胰腺肿瘤 原癌基因蛋白质c-met |
Research progress of HGF/c-MET signaling pathway inhibitors in anti-pancreatic cancer |
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| Qiao Yin-biao,Yang Bo.Research progress of HGF/c-MET signaling pathway inhibitors in anti-pancreatic cancer[J].Journal of International Oncology,2017,44(4). |
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| Authors: | Qiao Yin-biao Yang Bo |
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| Abstract: | Pancreatic cancer is one of the most malignant tumors.Targeted therapy has become an important part of the treatment of pancreatic cancer.The signaling pathways such as hepatocyte growth factor/c-MET (HGF/c-MET) signaling pathway, inhibition of which may exerts an antitumor effect, play extremely important roles in the occurrence and development of pancreatic cancer.Therefore, the research of HGF/c-MET targeted inhibitors opens up a new avenue for treatment of pancreatic cancer. |
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| Keywords: | Hepatocyte growth factor Pancreatic neoplasms Proto-oncogene proteins c-met |
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