Rga (Rodgers) and the HLA Region: Linkage and Associations |
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| Authors: | CM Giles T Gedde-Dahl Jr EB Robson E Thorsby B Olaisen A Arnason F Kissmeyer-Nielsen I Schreuder |
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| Institution: | MRC Blood Group Reference Laboratory, London, England;;Genetics Laboratory, Norsk Hydro's Institute for Cancer Research, Oslo, Norway;;MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, London, England;;Tissue Typing Laboratory, University Hospital, Oslo, Norway;;institute of Forensic Medicine, University of Oslo, Oslo, Norway;;Department of Human Genetics, Birmingham Maternity Hospital, Birmingham, England and Blood Bank, Reykjavik, Iceland;;Blood Grouping Laboratory, University Hospital, Aarhus, Denmark;;Department of Immunohaematology, University Hospital, Leiden, The Netherlands |
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| Abstract: | In 19 families with 97 children the segregation of Rga (Rodgers) was found to be compatible with Mendelian inheritance and five backcross and 14 intercross families were found among HLA and Bf typed families. Close linkage (lods + 17.82) without recombination was found between Rg and the HLA region, with a direct count of 96 nonrecombinant meioses for Rg-HLA-B. Kg- was strongly associated with HLA-B8 (29 of 30 haplotypes) and probably associated with Bw40, but did occur on other HLA-B haplotypes. By inference.Rg- is negatively associated with Ch- (Chido). The Rg-Ch- haplotype has not been observed. Rg3 and Cha may or may not be coded for by different sites of the same cistron closely linked to HLA-B:C and cannot as yet be excluded from being parts of B or C. |
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