Vildagliptin in the treatment of type 2 diabetes mellitus |
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Authors: | Stamataros George Schneider Stephen H |
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Affiliation: | UMDNJ-Robert Wood Johnson Medical School, Division of Endocrinology, Metabolism and Nutrition, One Robert Wood Johnson Place, New Brunswick, NJ 08903, USA. stamatge@umdnj.edu |
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Abstract: | INTRODUCTION: Inhibition of dipeptidyl peptidase IV (DPP-4) augments glucose-dependent insulin release and is a new approach to the treatment of type 2 diabetes (T2DM). Vildagliptin is a new DPP-4 inhibitor approved in many countries for the treatment of T2DM. This review provides an overview of vildagliptin with emphasis on its pharmacology and clinical effectiveness. AREAS COVERED: Results of preclinical and several Phase II and III studies from 2004 - 2010 are discussed. EXPERT OPINION: Vildagliptin acts to inhibit the breakdown of glucagon-like peptide (GLP)-1, which in turn enhances the beta-cell response to glucose and inhibits glucagon secretion. It is an effective agent alone or in combination in patients with T2DM, resulting in modest improvements in HbA1c usually in the 0.5 - 1% range. Advantages include weight neutrality and a lesser incidence of hypoglycemia. Concerns remain regarding its use in renal disease and potential complications seen in animal models. |
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