复方银黄微型灌肠剂家兔体内药代动力学研究

目的:测定复方银黄微型灌肠剂的药代动力学参数,为临床合理用药提供科学依据。方法:采用高效液相色谱法测定黄芩苷和绿原酸在家兔体内的血药浓度,采用药动学程序3P97进行统计处理,确定药动学模型及相关药代动力学参数。结果:黄芩苷在家兔体内呈二室模型分布,其药代动力学参数是:t_1/2α0.311 h,t_1/2β1.640 h,AUC 1.531×10^-2g.h.L^-1,t_max0.287 h,Vd 2.182 L;绿原酸在家兔体内呈二室模型分布,其药代动力学参数是:t_1/2α0.324 h,t_1/2β1.206 h,AUC 2.135×10^-2g.h.L^-1,tmax0.317 h,Vd 2.251 L。结论:复方银黄微型灌肠剂经直肠给药后其主要成分黄芩苷和绿原酸吸收迅速、完全,具有优良的药代动力学特征。

Pharmacokinetics study on Yinhuang compound microenema in rabbits

OBJECTIVE: To determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema. METHOD: HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema. RESULT: Baicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.311 h, t(1/2)beta of 1.640 h, AUC of 1.531 x 10(-2) g x h x L(-1), tmax of 0.287 h, Vd of 2.182 L. Chlorogenic acid showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.324 h, t(1/2)beta of 1.206 h, AUC of 2.135 x 10(-2) g x h x L(-1), tmax of 0.317 h,Vd of 2.251 L. CONCLUSION: The main components in Yinhuang compound microenema baicalin and chlorogenic acid are absorbed quickly and absolutely after rectal administration, which have good characters of pharmacokinetics.