| 莫索尼定对去缓冲神经大鼠延髓腹外侧头端神经元自发电活动的影响 |
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| 引用本文： | 许彦芳,范振中,何瑞荣.莫索尼定对去缓冲神经大鼠延髓腹外侧头端神经元自发电活动的影响[J].中国药理学与毒理学杂志,1999,0(2):81-84. |
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| 作者姓名： | 许彦芳 范振中 何瑞荣 |
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| 作者单位： | (河北医科大学生理学教研室, 石家庄 050017) |
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| 摘 要： | 在去缓冲神经大鼠观察莫索尼定对延髓腹外侧头端区 (RVLM) 神经元自发电活动的影响. 向颈总动脉内注射莫索尼定2, 10, 50 μg·kg-1后, 同步记录神经元放电图，血压及心率. 结果显示,莫索尼定剂量依赖性地降低RVLM 神经元放电率，血压和心率. 莫索尼定10, 50 μg·kg-1使放电率分别减少23% 和41%. 动脉注射选择性I1-咪唑啉受体阻断剂依法克生10 μg·kg-1, 可完全拮抗莫索尼定10 μg·kg-1 的作用. 结果提示, 莫索尼定通过激动延髓腹外侧头端区神经元上的I1-咪唑啉受体,抑制其自发放电活动.
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| 关 键 词： | 莫索尼定 依法克生 延髓 电位测定法 血压测定 心率 |
| 收稿时间： | 1997-12-9 |
Effect of moxonidine on spontaneous activity of rostral ventrolateral medullary neurons in barodenervated rats |
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| XU Yan-Fang, FAN Zhen-Zhong, HE Rui-Rong.Effect of moxonidine on spontaneous activity of rostral ventrolateral medullary neurons in barodenervated rats[J].Chinese Journal of Pharmacology and Toxicology,1999,0(2):81-84. |
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| Authors: | XU Yan-Fang FAN Zhen-Zhong HE Rui-Rong |
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| Institution: | (Department of Physiology, Hebei Medical University, Shijiazhuang 050017) |
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| Abstract: | The effect of moxonidine (Mox) on spontaneous activity of neurons in the rostral ventrolateral medulla (RVLM) was studied in barodenervated rats. Electroneurogram, blood pressure (BP), and heart rate (HR) were simultaneously recorded after intracarotid arterial injection of Mox 2, 10 and 50 μg·kg-1. The results showed that Mox dose- dependently reduced discharge rate of RVLM neurons, BP and HR. Mox 10, 50 μg·kg-1 decreased discharge rate of RVLM neurons by 23% and 41%, respectively. Efaroxan(10 μg·kg-1, ia), a selective I1- imidazoline antagonist, completely prevented the inhibitory responses to Mox 10 μg·kg-1. It is suggested that Mox decrease spontaneous activity of RVLM neurons via I1-imidazoline receptors. |
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| Keywords: | moxonidine efaroxan medulla oblongata potentiometry blood pressure determination heart rate |
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