| IL-2联合吡柔比星膀胱灌注预防膀胱癌复发 |
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| 引用本文： | 王名伟,张志伟,郭喜勇. IL-2联合吡柔比星膀胱灌注预防膀胱癌复发[J]. 蚌埠医学院学报, 2001, 26(6): 483-484 |
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| 作者姓名： | 王名伟 张志伟 郭喜勇 |
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| 作者单位： | 上海第二医科大学附属瑞金医院卢湾分院泌尿外科, |
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| 摘 要： | 目的：探讨生物制剂联合化疗药物膀胱灌注预防膀胱癌术后复发的机制。方法：对比研究白细胞介素2（IL－2）和吡柔比星联合膀胱灌注与单用吡柔比星膀胱灌注前后患者血、尿肿瘤坏死因子（TNF）和血IL－2受体的动态变化。结果：联合膀胱灌注组的TNF和IL－2受体水平显著高于吡柔比星组（P＜0．01）。结论：联合灌注组机体的细胞免疫功能得到更好改善，IL－2增加肿瘤细胞对免疫反应的应答，两者间有免疫促进及协同作用。
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| 关 键 词： | 膀胱肿瘤 投药 吡柔比星 白细胞介素2 复发 |
| 文章编号： | 1000-2200(2001)06-0483-02 |
| 修稿时间： | 2000-10-10 |
Intravesical instillation of IL-2 together with pirarubicin in the prevention of bladder cancer recurrence |
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| WANG Ming wei,ZHANG Zhi wei,GUO Xi yong. Intravesical instillation of IL-2 together with pirarubicin in the prevention of bladder cancer recurrence[J]. Journal of Bengbu Medical College, 2001, 26(6): 483-484 |
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| Authors: | WANG Ming wei ZHANG Zhi wei GUO Xi yong |
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| Abstract: | Objective:To explore the effects of intravesical instillation of pirarubicin together with IL 2 on patients with bladder cancer,who had undergone surgical operation.Methods:The change of serum and urine TNF level and IL 2 receptor level in patients treated by intravesical instillation of pirarubicin alone or together with IL 2 were analysed.Results:Levels of TNF and IL 2 receptor were found to increase significantly after combined instillation of pirarubicin and IL 2( P <0.01).Conclusions:Intravesical instillation of pirarubicin together with IL 2 can improve cellular immunological function and IL 2 can improve immunological response of the tumor cells. |
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| Keywords: | bladder neoplasms administration intravesical pirarubicin interleukin 2(IL - 2) |
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