Papain-induced lung injury: alterations in connective tissue metabolism without emphysema |
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Authors: | J F Collins L S Durnin W G Johanson |
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Institution: | Veterans Administration Hospital, and the Departments of Medicine and Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA |
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Abstract: | The acute effects of the deposition of papain in the lungs of 4-month-old rabbits have been investigated with an amount not sufficient to cause emphysematous changes. During the first 2 days of in vivo deposition when hemorrhaging and inflammation occur, the total amounts of collagen and elastin in the lung, into which the papain had been instilled, did not change but the concentrations of collagen and elastin decreased 20 and 25% respectively. The rates of synthesis of collagen and other proteins doubled. By 4 weeks, collagen and elastin concentrations returned to, or were slightly above, control levels. The histological appearance and mean linear intercepts of lung sections and the compliance curves of excised lungs of the treated animals were similar to controls by 2 weeks after papain administration. The rabbit lung thus appears able to repair mild injury due to proteolytic enzymes. |
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Keywords: | Address all correspondence to Dr James F Collins Research Service (151) Audie L Murphy Memorial Veterans Hospital 7400 Merton Minter Boulevard San Antonio Texas 78284 |
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