葡萄糖酸钙防治改良FOLFOX4方案治疗晚期胃肠肿瘤神经毒性观察

目的:观察葡萄糖酸钙防治改良FOLFOX4方案治疗晚期胃肠肿瘤神经毒性。方法:将196例胃肠肿瘤患者随机分为A、B两组,A组85例予以葡萄糖酸钙+改良FOLFOX4方案,在用草酸铂前、后缓慢推注5%葡萄糖溶液20ml+10%葡萄糖酸钙10ml各1次,每2周重复。B组111例采用改良FOLFOX4方案。结果:A组总有效率为45.88%,B组总有效率为46.85%,两组差异无统计学意义(P>0.05);A组神经毒性发生率为49.41%,B组为65.77%,两组差异有统计学意义(P<0.05)。结论:葡萄糖酸钙防治草酸铂神经毒性疗效好,且不影响含草酸铂的改良FOLFOX4方案临床疗效。

Calcium gluconate combined with modified FOLFOX4 regimen for treatment of advanced gastric and colorectal carcinoma

Objective：To assess the neuroprotectant effect of Calcium gluconate combined with modified FOLFOX4 regimen on oxaliplatin-induced neurotoxicity.Methods：One hundred and ninety-six patients were randomly divided into two groups.Group A were administered modified FOLFOX4 regimen and Calcium gluconate.They were administered infusion of 5% Calcium gluconate（1 g）before and after oxaliplatin,and the regimen was repeated every two weeks.Group B received modified FOLFOX4 regimen only.Results：The response rate was 45.88%（39/85）and 46.85%（52/111）in group A and group B respectively（P〉0.05）,and the incidence of neurotoxicity was 49.41% and 65.77% in group A and group B respectively（P〈0.05）.Conclusions：Infusion of Calcium gluconate can effectively reduce the incidence of oxaliplatin-induced neurotoxicity without interfering the effect of modified FOLFOX4 regimen.