Synthesis and anti-inflammatory, antipyretic and analgesics properties of 5-(1,2-benzisothiazolyl)tetrazoles

Tetrazole analogs of a series of known 1,2-benzisothiazolalkanoic acids were synthesized and tested for anti-inflammatory, antipyretic and analgesic activities in comparison with their corresponding carboxylic acids. The benzisothiazoliltetrazoles showed high antipyretic activity and each tetrazole, except one, was appreciably more potent than the corresponding acid. The examined tetrazoles are generally inactive as anti-inflammatory agents and weakly active in the mouse writhing test, with effect comparable with those of the corresponding carboxylic acids.