丹参对瑞舒伐他汀在大鼠体内药代动力学的影响

目的 研究丹参对瑞舒伐他汀在大鼠体内药代动力学影响.方法 12只雄性大鼠,体质量(230±15)g,随机分为2组:单用瑞舒伐他汀组(80mg/kg)与瑞舒伐他汀合用丹参(400 mg/kg)组,每组6只,分别于给药前及给药后0.5、1、1.5、3、5、8、10、12、24 h时从眼眶静脉采血约0.3 ml,采用LC-MS测定血药浓度,比较两组间药代参数,利用SPSS12.0软件进行统计学处理.结果 合用丹参后瑞舒伐他汀药代动力学参数Cmax、AUC0-t、AUC0-∞分别增加60.81％、88.00％和82.92％,而T1/2与CLz/F值分别降低了33.21％和21.51％.结论 大鼠体内丹参可影响瑞舒伐他汀的药代动力学特性.

Effect of Danshen on pharmacokinetics of Rosuvastatin in rats

Objective To study the effect of Danshen on the pharmacokinetics of Rosuvastatin in rats.Methods Parallel control method was applied in this study.Twelve male rats weighing(230±15) g were evenly randomized into two groups: rosuvastatin(80 mg/kg) group and Rosuvastatin plus Danshen(400 mg/kg) group.Blood samples(0.3 ml each) were collected from the orbital vein at 0.5,1,1.5,3,5,8,10,12 and 24 h after drug administration.LC-MS was used to determine the plasma concentrations of Rosuvastatin.The pharmacokinetic parameters of the two groups were compared and statistical analysis was performed using SPSS12.0 software.Results When combined with Danshen,the Cmax,AUC0-t,and AUC0-∞ of Rosuvastatin were increased by 60.81%,88.00% and 82.92%,and T1/2 and CLz/F were reduced by 33.21% and 21.51%,respectively.Conclusion Danshen can affect the pharmacokinetic properties of Rosuvastatin in rats.