| 几种常见风湿病患者血中B细胞刺激因子的变化及意义 |
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| 引用本文： | 蒋莉,王晓非,袁双龙,张晓莉,郭韵,吴春玲,陈涓涓. 几种常见风湿病患者血中B细胞刺激因子的变化及意义[J]. 中国医科大学学报, 2008, 37(1): 103-104 |
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| 作者姓名： | 蒋莉 王晓非 袁双龙 张晓莉 郭韵 吴春玲 陈涓涓 |
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| 作者单位： | 1. 中国医科大学 附属第一医院风湿免疫科,沈阳,110001
2. 中国医科大学 第90期临床医学系,沈阳,110001 |
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| 基金项目： | 辽宁省教育厅高等学校科研基金资助项目(040167) |
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| 摘 要： | 目的探讨几种常见的风湿性疾病患者血中B细胞刺激因子(BAFF)的变化及临床意义。方法采用ELISA方法对各种风湿病患者及健康对照者血中BAFF进行测定。结果几种常见的风湿性疾病(SLE、RA、SS、AS)患者血中BAFF明显高于正常对照组;各组疾病患者血中BAFF的水平变化与各种疾病活动性指标呈明显相关改变。结论BAFF在风湿性疾病的发生发展中具有重要作用,抑制BAFF的产生或降低其水平可能成为风湿病治疗的有效方法之一。
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| 关 键 词： | 风湿病 B细胞刺激因子 |
| 文章编号： | 0258-4646（2008）01-0103-02 |
| 收稿时间： | 2007-09-10 |
| 修稿时间： | 2007-09-10 |
The Serum Levels and Significance of B Cell Activating Factor in Some Frequent Rheumatic Ddisease |
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| JIANG Li,WANG Xiao-fei,YUAN Shuang-long,ZHANG Xiao-li,GUO Yun,WU Chun-ling,CHEN Juan-juan. The Serum Levels and Significance of B Cell Activating Factor in Some Frequent Rheumatic Ddisease[J]. Journal of China Medical University, 2008, 37(1): 103-104 |
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| Authors: | JIANG Li WANG Xiao-fei YUAN Shuang-long ZHANG Xiao-li GUO Yun WU Chun-ling CHEN Juan-juan |
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| Abstract: | Objective To investigate the serum levels and clinical significance of B cell activating factor (BAFF) in some frequent rheumatic disease. Methods The serum levels of BAFF in rheumatic disease patients and normal controls were determined by ELISA. Results The serum levels of BAFF in frequent rheumatic disease were higher significantly than that of normal controls.In every kind of rheumatic disease,there was obvious correlation between the levels of BAFF and disease activity index. Conclusion BAFF plays a key role in the development of rheumatic disease. Inhibiting the production of BAFF and decreasing the levels of BAFF may be become one of available therapy for SLE. |
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| Keywords: | rheumatic disease B cell activating factor |
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