Involvement of Akt1/protein kinase Bα in tumor conditioned medium-induced endothelial cell migration and survival in vitro |
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| Authors: | Ming Li Tu Han Qin Wang Long Ju Chen Jin Chang Lu Fei Jiang Jiang Hong Liang Da Guo Xu Dong Sheng Li |
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| Institution: | (1) Department of Respiratory Medicine, Yunyang Medical College Taihe Hospital, Hubei, China;(2) Hubei Provincial Key Laboratory of Embryonic Stem Cell Research, Yunyang Medical College Taihe Hospital, 30 Ren Ming Nan Road, 442000 Hubei, Shiyan, China;(3) Department of Anatomy, Yunyang Medical College, Hubei, China;(4) Department of Obstetrics and Gynecology, Yunyang Medical College Taihe Hospital, Hubei, China; |
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| Abstract: | Purpose Endothelial cell migration and survival might be called “major angiogenic responses”. Tumor conditioned medium (CM) has been
widely used to stimulate endothelial cells to form capillary-like structures in angiogenesis models in vitro. However, the
molecular events triggered by tumor CM are not fully understood. Here, we examined the effects of the CM from human lung carcinoma
cell lines A549 and SPC-A-1 on cultures of primary human umbilical veins endothelial cells (HUVECs). |
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