| 吡咯里西啶生物碱的细胞毒性及致毒机制研究进展 |
| |
| 引用本文： | 王军,王长虹,王峥涛.吡咯里西啶生物碱的细胞毒性及致毒机制研究进展[J].国际药学研究杂志,2007,34(4):246-249,258. |
| |
| 作者姓名： | 王军 王长虹 王峥涛 |
| |
| 作者单位： | 1. 上海中医药大学中药研究所,中药标准化教育部重点实验室,上海,201203;安徽中医学院药学院,安徽,合肥,230031
2. 上海中医药大学中药研究所,中药标准化教育部重点实验室,上海,201203;上海中药标准化研究中心,上海,201203 |
| |
| 基金项目： | 国家自然科学基金
,
国家自然科学基金 |
| |
| 摘 要： | 吡咯里西啶生物碱广泛分布于6 000多种高等植物中，是一类肝毒性很强的天然产物。吡咯里西啶生物碱在肝脏代谢成活性代谢物吡咯后产生肝毒性。利用体外细胞毒性研究方法评价吡咯里西啶生物碱的毒性，对于阐明吡咯里西啶生物碱的致毒机制，研究开发拮抗其毒性的药物及保证临床用药安全具有重要意义。本文对吡咯里西啶生物碱的细胞毒性及致毒机制的研究进展进行综述。
|
| 关 键 词： | 吡咯里西啶生物碱 细胞毒性 |
| 收稿时间： | 2006-11-30 |
Advancement of investigation on cytotoxicity and mechanism of pyrrolizidine alkaloids |
| |
| WANG Jun,WANG Chang-hong,WANG Zheng-tao.Advancement of investigation on cytotoxicity and mechanism of pyrrolizidine alkaloids[J].Foreign Medical Sciences(Section of Pharmarcy),2007,34(4):246-249,258. |
| |
| Authors: | WANG Jun WANG Chang-hong WANG Zheng-tao |
| |
| Institution: | WANG Jun1,3, WANG Chang-hong1,2, WANG Zheng-tao1,2 |
| |
| Abstract: | Pyrrolizidine alkaloids are a large class of natural products with hepatotoxicity and have been identified in more than 6 000 plant species. Pyrrolizidine alkaloids are activated by metabolic activation in liver and their parent compounds are converted into active “pyrrole” which may produce hepatotoxicity. It has important significance to evaluate the cytotoxicity of pyrrolizidine alkaloids in vitro for illuminating hepatotoxic mechanisms of pyrrolizidine alkaloids, finding drugs against the toxicity of pyrrolizidine alkaloids, and guaranteeing clinical medication security. In the present paper, the advancement of research on the cytotoxicity and mechanism of pyrrolizidine alkaloids are reviewed. |
| |
| Keywords: | pyrrolizidine alkaloids cytotoxicity |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《国际药学研究杂志》浏览原始摘要信息 |
| 点击此处可从《国际药学研究杂志》下载免费的PDF全文 |
|
