遗传性非息肉病性大肠癌两种手术方式疗效分析

目的:探讨遗传性非息肉病性大肠癌理想的手术方式.方法:回顾性分析1990年8月～2002年8月我院普外科收治的31例遗传性非息肉病性大肠癌的临床资料,17例接受大肠癌次全切术,14例接受大肠癌常规手术.比较手术前、后患者体重、血浆营养参数(血红蛋白、血清白蛋白)以及术后排便次数、术后复发率在两种手术方式组间的差异.结果:患者的体重变化、血红蛋白、血浆蛋白的变化及术后每天排便次数在两种术式组中无明显差异(P＞0.05);次全大肠切除术组复发率比常规手术方式组低,二者相比具有统计学差异(P＜0.05).结论:次全结肠切除术较大肠癌常规手术更适合于遗传性非息肉病性大肠癌的治疗.

Analysis of Curative Effect on Patients with Hereditary Nonpolyposis Colorectal Cancer Underwent Two Types of Colectomy

Objective: To evaluate the optimum surgical management for patient with hereditary nonpolyposis colorectal cancer (HNPCC). Methods: From August 1990 to August 2002, 31 patients with HNPCC confirmed with the Japan criteria, underwent subtotal colectomy or routine colectomy. The clinical datas were analyzed, including the decrease of weight, hemoglobin, serum albumin pre-and post-operation, the frequency of excretion everyday and the recurrence rate after operation. The difference were compared between patients underwent subtotal colectomy and those underwent routine excision. Results: As compared with the patients with routine colectomy, there was on significant difference of the weight lose, quantity of the hemoglobin and the serum albumin between the two groups of patients. The frequency of excretion of patients underwent subtotal colectomy was more than that of patients underwent routine colectomy everyday, but there was no significant difference between two groups. As compared with patients underwent routine colectomy, the recurrence rate after operation of the patients underwent subtotal colectomy are significantly lower. Conclusion: For patients with HNPCC, the subtotal colectomy is preferable than the routine excision.