盐酸丁咯地尔治疗糖尿病周围神经病变48例的疗效

目的:观察盐酸丁咯地尔注射液治疗糖尿病周围神经病变的疗效及安全性.方法:将48例住院患者随机分为两组,两组均常规行降糖药物治疗,试验组(n=25)加用盐酸丁咯地尔注射液200 mg加入生理氯化钠溶液250 mL中静滴,qd,对照组(n=23)用复方丹参注射液16 mL加入生理氯化钠溶液250 mL中静滴,qd.两组均14 d为1个疗程,间隔2 d再用1个疗程,总疗程30 d.评价两组治疗前后有效率以及感觉神经传导速度(SCV).结果:试验组总有效率为88.0%,明显高于对照组60.8%,两组比较差异有显著性(P＜0.05),与对照组比较,试验组正中神经、尺神经、腓总神经和胫神经的SCV均有提高(P＜0.05),主要的不良反应为上腹部不适、头晕、嗜睡等,对症处理后症状消失.结论:盐酸丁咯地尔注射液治疗糖尿病周围神经病变疗效满意.

Efficacy of buflomedil hydrochloride for injection in the treatment of diabetic peripheral neuropathy

Objective:To evaluate the efficacy and safety of buflomedil hydrochloride for injection in the treatment of diabetic peripheral neuropathy.Methods:48 inhospitalized patients with diabetic peripheral neuropathy were randomly assigned to one of treatment groups: the treatment group(n=25) received adjuvant therapy of conventional glucose-controlled drug with buflomedil hydrochloride for injection(200 mg),the control group(n=23) administered the combination of conventional glucose-controlled drug with a compound Salvia miltiorrhiza for injection(total 16 mL).Both groups were infused once daily for 14 days.The therapeutic regimens were repeated for additional 14 days in a 2-day interval after the first cycle of the 14-day therapy.The efficacy of the therapy was assessed based on the SCV(sensery nerves conduction velocity) status prior to and post therapy.Results:The total efficacy rate of the treatment and control group showed a significant difference(88.0% vs.60.8%,P<0.05).Compared to the control group,the patients in the treatment group experienced significant improvements of the SCV(P<0.05).The common adverse events in the treatment of buflomedil hydrochloride for injection were abdominal disorder,dizzy and somnolence.Conclusion:Buflomedil hydrochloride for injection showed an adjuvant therapeutic benefit in the treatment of diabetic peripheral neuropathy.