Effect of gamma interferon on resolution of murine chlamydial genital infection. |
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| Authors: | R G Rank K H Ramsey E A Pack D M Williams |
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| Affiliation: | Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock 72205. |
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| Abstract: | Mice infected in the genital tract with the Chlamydia trachomatis agent of mouse pneumonitis were treated with monoclonal rat anti-gamma interferon (anti-IFN-gamma) antibody to determine whether IFN-gamma participated in the resolution of the infection. In two experiments, anti-IFN-gamma antibody treatment resulted in significantly prolonged infections. In support of these data, passive administration of recombinant IFN-gamma to chronically infected nu/nu mice was able to bring about resolution of the infection in some animals. |
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