Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre,Malawi |
| |
| Authors: | Cunliffe Nigel A Dove Winifred Gondwe Jailosi S Thindwa Benson D M Greensill Julie Holmes Jennifer L Bresee Joseph S Monroe Stephan S Glass Roger I Broadhead Robin L Molyneux Malcolm E Hart C Anthony |
| |
| Institution: | Wellcome Trust Research Laboratories, Universities of Malawi and Liverpool, College of Medicine, Blantyre, Malawi. n.a.cunliffe@liv.ac.uk |
| |
| Abstract: | In a 2-year hospital-based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV-1 (25%), HAstV-2 (21%), HAstV-3 (25%), HAstV-4 (13%), HAstV-5 (4%), and HAstV-8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease. |
| |
| Keywords: | astrovirus HIV Malawi |
| 本文献已被 PubMed 等数据库收录！ |
|
