Late and acute adverse reactions to iohexol in a pediatric population

The purpose of this study was to determine the incidence of acute and late reactions after contrastmedium injection in the Finnish paediatric population. From March 1989 to November 1990, 321 children under 19 years of age were examined with a nonionic contrast medium, iohexol, for urography and CT. The follow-up time for late reactions was up to 24 h after the contrast-medium injection. The return rate for the questionnaires given to patients to record their reactions was 73.2%. Acute adverse reaction was noted in 1.9% of the patients, with the most frequent reactions being in the weight range 24–40 kg. Asthma and previous reactions to contrast medium are risk factors for acute reaction. Late reactions were found in 6.2% of the patients, most frequently in children weighing under 24 kg.