| 衰坏生物瓣氨基酸含量变化研究 |
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| 引用本文： | 张道全,刘维永,张卫达. 衰坏生物瓣氨基酸含量变化研究[J]. 西南国防医药, 1995, 0(3) |
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| 作者姓名： | 张道全 刘维永 张卫达 |
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| 作者单位： | 解放军59医院，解放军第四军医大学西京医院胸外科，解放军第四军医大学西京医院胸外科 661000 |
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| 摘 要： | 本文对长期植入人体后衰坏(failure)而摘除的生物瓣进行了氨基酸含量变化分析。结果表明:羟脯氨酸与羟赖氨酸含量明显下降,从而证实了胶原纤维的退变,进一步从生化角度支持了形态学观察结果,为新型生物瓣膜的研制提供了依据。
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| 关 键 词： | 生物瓣膜 氨基酸 退变 |
CHANGES OF AMINO ACJD CONCENTRATION IN FAILING PORCINE BIOPROS-THETIC HEART VALVES |
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| Zhang Daoquan,Liu Weiyong,Zhang Weida. CHANGES OF AMINO ACJD CONCENTRATION IN FAILING PORCINE BIOPROS-THETIC HEART VALVES[J]. Medical Journal of National Defending forces in Southwest China, 1995, 0(3) |
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| Authors: | Zhang Daoquan Liu Weiyong Zhang Weida |
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| Affiliation: | Zhang Daoquan,Liu Weiyong,Zhang Weida,Department of Thoracic and Cardiovascular Surgery,Army Hospital 59,Chengdu Millitary Com-mand Kuming,661000 |
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| Abstract: | It was detected the concentrations of 8 kinds of amino acids in 5 porcine bioprosthetic heart valves (tested group)which had been removed from the hosts due to the failure after long - term implantation^ 71 to 149 months). At the same time,the concentrations of these amino acids in 7 porcine aortic valves (control group)were detectde, too. It was found that the concentrations of the hydrox-yproline and hydroxlysine decreased very significantly (P<0. 001)and ones of the histidine and thre-omine increased greatly (P<0. 05) in the tested group , compared with those in the control group. The decreases of the hydroxyproline and hydroxlysine indicated the degeneration of the collagen in the failing porcine bioprosthetic heart valves , which confirmed the former result of the morphological observa- |
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| Keywords: | bioprosthetic heart valve amino acid degeneration |
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