Inflammatory bowel disease and coronary artery disease |
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Authors: | Raja Shekhar R Sappati Biyyani Nabil M Fahmy Elizabeth Baum Karl M Nelson James F King |
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Institution: | (1) Metro Health Medical Center, 2500 Metro Health Drive, Cleveland, OH 44109, USA;(2) Canton Medical Education Foundation, 2600 6th Street SW, Canton, OH 44710, USA;(3) Aultman Hospital, 2600 6th Street SW, Canton, OH 44710, USA;(4) Gastroenterology & Hepatology Specialists Inc., 4360 Fulton Drive, NW, Suite B, Canton, OH 44718, USA |
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Abstract: | Chronic inflammation with the presence of excess serum acute-phase proteins, cytokines and cell adhesion molecules is increasingly
being implicated in atherosclerosis. The association between inflammatory bowel disease (IBD) and coronary artery disease
(CAD) is unstudied. This is a preliminary, thesis-generating cross-sectional study aimed at evaluating the presence of traditional
atherosclerotic risk factors in patients with IBD and CAD compared with the control population. The medical records of 42
consecutive IBD patients with CAD from 1999 to 2005 (27 men) were reviewed for the Framingham risk factors. The Framingham
risk score (FRS) is calculated based on age, sex, hypertension, diabetes and hyperlipidemia. FRS of patients with IBD and
CAD was compared with the FRS of 137 age- and sex-matched (102 men) consecutive patients with CAD (controls). When the Framingham
risk score adjusted for group and gender with age as a covariate, the adjusted total FRS score was higher in patients with
CAD alone (10.0 3.75]) as compared to those with; IBD and CAD: (8.1 3.47]; p = 0.001). FRS is lower in cases (patients with IBD and CAD) when compared with the controls (CAD alone). |
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Keywords: | Framingham Heart Study Multivariate models Pathogenesis of atherosclerosis |
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