常温和中低温体外循环对甲状腺素变化的影响

目的探讨常温及低温体外循环心脏直视手术对甲状腺素的影响。方法选择先天性心脏病患者80例，随机分为常温组及低温组，各40例，分别于术晨、体外循环结束时及术后6、12、24、48h抽取患者动脉血，测定血浆T3、T4和TSH。结果两组术前各项检查指标差异无统计学意义。常温体外循环下甲状腺素T3升高水平低于中低温，恢复时间比中低温明显缩短。结论常温体外循环心脏直视手术对甲状腺素的影响显著轻于低温组，因而术后机体的恢复优于低温方法。

Effects of normothermic and hypothermic cardiopulmonary bypass on thyroid hormone

Objective To explore the detrimental influence of normothermic and hypothermic cardiopulmonary bypass （CPB） during open heart surgery on thyroid hormone. Methods Eighty patients with congenital heart disease were randomized into 2 groups to receive normothermic cardiopulmonary bypass （CPB, study group, n=20）or hypothermic CPB （control group, n=20）. Arterial blood samples were respectively collected at scheduled time points preoperatively at the end of CPB, and 6,12,24,48 hour postoperatively to examine the level of T3, T4, TSH. Results The levels of thyroid hormone T3 increased and recovery time was shorter significantly in normothermic than hypothermia CPB. Conclusion Open-heart surgery under normothermic CPB has less detrimental influence on thyroid hormone and the recovery is better than the operation under hypothermic CPB.