三种药物联合治疗老年类风湿关节炎伴骨质疏松患者的疗效观察

目的探讨鲑鱼降钙素联合钙尔奇D、阿法骨化醇治疗老年类风湿关节炎伴骨质疏松患者的疗效及安全性。方法选取40例老年类风湿关节炎伴骨质疏松症患者随机分为两组，对照组服用钙尔奇D片（钙尔奇D600）、阿法骨化醇，治疗组在对照组的基础上加用鲑鱼降钙素注射液，两组均连续治疗半年，观察治疗前后的骨密度和疼痛变化。结果两组治疗后骨密度均明显上升，与治疗前比较差异有统计学意义（P〈0．05）。治疗后治疗组骨密度明显高于对照组，差异有统计学意义（P〈0．05）。治疗后两组VAS评分均明显下降，与治疗前比较差异有统计学意义（P〈0．05），治疗后治疗组VAS评分下降程度高于对照组，差异有统计学意义（P〈0．05）。结论鲑鱼降钙素联合钙尔奇D、阿法骨化醇治疗老年类风湿关节炎伴骨质疏松症患者安全、临床疗效好，优于钙尔奇D及骨化醇治疗。

Clinical observation three kinds of drug combination therapy with elderly rheumatoid arthritis patients with osteoporosis

Objective To explore the safety and efficacy of Salmon of calcitonin joint calcium eq D and Alfacalcidol treat-ment in Senile rheumatoid arthritis complicated with osteoporosis patients.Methods Selected 40 elderly cases of rheuma-toid arthritis complicated with osteoporosis patients,randomly divided the control group taking calcium eq D piece(calci-um eq D600)and Alfacalcidol,the treatment group combined with salmon of calcitonin injection.Both groups continuous treated for half a year,observed bone mineral density and pain changes before and after treatment.Results After treatment the two groups were significantly increased bone density,compared with before treatment had a significant difference(P < 0.05).In treatment group was obviously higher than the control group with bone mineral density,there was statistical sig-nificant difference(P < 0.05).In two groups after treatment,VAS(Visual Analogue Scale/Score)score were significantly decreased,had a significant difference(P < 0.05),after treatment were observed in group VAS score decreased degree higher than that in the control group,there was statistical significant difference(P < 0.05).Conclusion Salmon of calcitonin joint cal-cium eq D and Alfacalcidol treatment in Senile rheumatoid arthritis complicated with osteoporosis patients safety,clinical curative effect is good,better than calcium eq D and Alfacalcidol treatment.