芪丹饮对糖尿病肾病患者血液流变掌的影响

目的：观察芪丹饮对糖尿病肾病Ⅲ-Ⅳ期患者血液流变学影响。方法：将符合纳入标准的80例患者，随机分为治疗组、对照组各40例，常规给予胰岛素控制血糖，治疗组服用芪丹饮，1剂／d，早晚各服1次，每次约200ml；对照组服用福辛普利片（蒙诺）10mg，1次／d，疗程为2个月。观察治疗前后患者血糖、血脂水平、尿微量白蛋白、血肌酐（Scr）、尿素氮（BUN）及血液流变学指标。结果：①两组患者血糖、糖化血红蛋白、血脂治疗前后比较有明显降低，治疗组在改善血脂指标方面优于对照组。②两组患者尿微量白蛋白及肾功能指标治疗前后比较有明显改善，治疗组与对照组比较有明显差异。③治疗组对全血粘度低切、全血粘度高切、全血还原粘度高切、红细胞压积的降低作用优于对照组。结论：芪丹饮可显著减少糖尿病肾病患者尿白蛋白排泄，改善’肾功能，改善血胆固醇、低密度脂蛋白，其机制可能与改善血液流变学有关。

The effect of Qidan Yin against the hemorheology of patients with DN

Objective:To observe the Qidan Yin to the DN Ⅲ-Ⅳ period of hemorheology in patients with influence.Methods:80 patients met the inclusion criteria,were randomly divided into treatment and control groups,40 each,the control group was given conventional insulin to control blood sugar for treatment,and the treatment group was treated with Qidan Yin,1/d,sooner or later,each serving a second,each about 200ml;control group taking fosinopril tablets(Monopril) of 10 mg /d treatment for two months.Before and after treatment blood glucose,lipid levels,microalbuminuria,serum creatinine(Scr),blood urea nitrogen(BUN) and hemorheology.Results:①Compared before and after treatment,the two groups of patients,blood sugar,glycated hemoglobin,blood fat is obviously decrease the treatment group was better than control group to improve blood fat index.②The two groups of patients’ microalbuminuria,and renal function index compared before and after treatment were obviously improved;the treatment group compared with controls has obvious difference.③The treatment group on whole blood viscosity low cut,whole blood viscosity high shear,whole blood reduced viscosity the high shear,red blood cell deposited reduces the than those in the control group.Conclusion:Qidan Yin can significantly reduce DN in patients with urinary albumin excretion and improve renal function,improve blood cholesterol,low density lipoprotein;the mechanism may improve blood rheology.