糖皮质激素对狼疮性肾炎患者肾内B淋巴细胞刺激因子的影响

目的探讨糖皮质激素(GC)对狼疮性肾炎(LN)患者血清及肾内B淋巴细胞刺激因子(BlyS)的影响。方法用ELISA法和免疫组化法检测LN患者与正常对照者的血清和肾内BlyS的表达水平。结果 LN患者血清及肾内BlyS的表达水平显著高于正常对照者(P<0.001);GC治疗>2周组的LN患者肾内BlyS的表达水平及系统性红斑狼疮疾病活动性指数(SLEDAI)评分较未治疗组显著减少(P分别为0.012和0.005)。结论 GC减轻LN患者疾病活动性的作用可能与其降低肾内BlyS水平有关。

The effect of glucocorticoid on the intrarenal expression of B lymphocyte stimulator in lupus nephritis patients

Objective To investigate the effect of glucocorticoid(GC) on the serum and intrarenal expression of B lymphocyte stimulator(BlyS) in patients with lupus nephritis(LN).Methods The serum and intrarenal expression of BlyS was respectively detected by ELISA and immunohistochemistry in LN patients and normal controls.Results The serum concentration and intrarenal production of BlyS in LN patients were significantly higher than that in normal controls(P<0.001).The intrarenal production of BlyS and the serum SLEDAI scores in LN patients that have received GC therapy more than 2 weeks were obviously lower than those in LN patients that haven′t received any treatment(P=0.012,0.005).Conclusion The effect of GC therapy on disease activity in LN patients may associate with the decreasing expression level of intrarenal BlyS.