首发精神分裂症患者认知功能好转的相关因素研究

目的 探讨精神分裂症患者在急性期与慢性期认知功能好转的相关因素。方法 对164例首发精神分裂症患者于治疗前、治疗三个月末和治疗三年末各做一次韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击试验、动作功能测验、手功能协调测验、连线测验A和B、威斯康星卡片分类测验(WCST)及言语流利性测验10项神经心理测查及BPRS、SANS、功能总体评定量表(GAF)、SIMP-SON药物副反应量表评定。结果 在急性期阴性症状好转程度越大,智力、记忆好转程度越大;在慢性期阴性症状、GAF以及副反应的改善与多种认知功能改善显著相关。结论 精神分裂症患者阴性症状、GAF、药物副反应的改善与认知功能好转有关,但在急性期和慢性期的特征不同。

Factors related to the cognitive function of first-episode schizophrenic patients

Objective: Discuss factors related to changes in cognitive function during the acute and chronic phases of schizophrenia. Methods: 10 cognitive function tests were administered-the Weschler Adult Intelligence Scale, Weschler Memory Scale, Grooved Pegboard Test, Finger Tapping Test, a motor function test, a hand coordination test, Trail Making Tests A and B, Wisconsin Card Sort Test, and a verbal fluency test-and the Brief Psychiatric Rating Scale, the Scale for Assessment of Negative Symptoms, the General Assessment of Functioning Scale and the Simpson side-effect scale to 164 first-episode schizophrenic patients at the time of admission, three months and 3 years after starting treatment. Results: During the acute treatment phase the greater the improvement in neagtive symptoms the greater the improvement in IQ and memory. During the chronic treatment phase, improvement in negative symptoms, side effects, and overall function were significantly correlated with improvement of several cognitive function measures. Conclusion: Improvement of negative symptoms, GAF and adverse effects in schizophrenics are correlated with cognitive function improvement, but may have different characteristics comparing acute phase with chronie phase.