Secretoneurin in bronchopulmonary carcinoids—immunohistochemical comparison with chromogranins A and B and secretogranin II |
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| Authors: | M. TÖ TSCH,B-C. PADBERG,S. SCHRÖ DER,D. Ö FNER,W. BÖ CKER,R. FISCHER-COLBRIE,K.W. SCHMID |
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| Affiliation: | Departments of Pathology, University of Münster, Germany;Institute of Clinical Pathology, University of Zürich, Switzerland;Department of Surgery I, University of Innsbruck, Austria;Department of Pharmacology, University of Innsbruck, Austria;University of Innsbruck, Austria |
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| Abstract: | Ninety-nine classical and 11 atypical bronchopulmonary carcinoids were investigated immunohistochemically with an antibody against secretoneurin, a peptide proteolytically processed from secretogranin II (chromogranin C), as well as antibodies against chromogranin A and B and secretogranin II. Secretoneurin was immunolocalized in 86 tumours (78 classical and eight atypical carcinoids); secretogranin II was found in the same tumours in a similar distribution, whereas chromogranin A was present in all 100 and chromogranin B in 106 tumours investigated. Bronchopulmonary carcinoids are usually not associated with clinically or biochemically distinct syndromes. Although we found bronchial carcinoids with different immunohistochemical chromogranins/secretogranin patterns, no correlation with the biological behaviour of these tumours could be demonstrated. |
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| Keywords: | carcinoid lung chromogranin A chromogranin B secretogranin II secretoneurin immunohistochemistry |
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