| 地塞米松对脑膜炎家兔脑脊液中可溶性细胞间黏附分子-1质量浓度变化的影响 |
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| 引用本文： | 刘俊举,薛艳,郭学鹏.地塞米松对脑膜炎家兔脑脊液中可溶性细胞间黏附分子-1质量浓度变化的影响[J].中国误诊学杂志,2010,10(14):3283-3285. |
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| 作者姓名： | 刘俊举 薛艳 郭学鹏 |
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| 作者单位： | 1. 江苏省扬州市第一人民医院儿科,225001
2. 河南省新乡医学院,453003 |
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| 摘 要： | 目的:探讨地塞米松(DEX)对脑膜炎家兔脑脊液(CSF)中可溶性细胞间黏附分子-1(sICAM-1)质量浓度变化的影响,为临床应用DEX辅助治疗脑膜炎提供理论依据。方法:家兔36只,随机分为模型组、地塞米松处理组和对照组;不同时点采集其脑脊液,采用ELISA法检测CSF中sICAM-1质量浓度。结果:模型组CSF sI-CAM-1质量浓度明显高于对照组同时相,差异有统计学意义(P均0.01);脑组织含水量高于对照组,差异有统计学意义(P0.01)。地塞米松处理组CSF sICAM-1质量浓度低于模型组同时相,差异有统计学意义(P均0.05),脑组织含水量低于模型组,差异有统计学意义(P0.05)。结论:细菌性脑膜炎(BM)病程中sICAM-1分泌增多,细胞间黏附分子-1(ICAM-1)参与脑水肿形成;DEX通过抑制ICAM-1表达和(或)分泌,而减轻血脑屏障损害,减轻脑水肿形成。
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| 关 键 词： | 胞间粘附分子1/血液 脑膜炎/血液 脑脊髓液 地塞米松/药理学 |
Effects of Dexamethasone on Soluble Intercellular Adhesion Molecule-1 in Cerebrospinal Fluid of Rabbits with Bacterial Meningitis |
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| LIU Jun-ju,XUE Yan,GUO Xue-peng.Effects of Dexamethasone on Soluble Intercellular Adhesion Molecule-1 in Cerebrospinal Fluid of Rabbits with Bacterial Meningitis[J].Chinese Journal of Misdiagnostics,2010,10(14):3283-3285. |
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| Authors: | LIU Jun-ju XUE Yan GUO Xue-peng |
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| Institution: | LIU Jun-ju,XUE Yan,GUO Xue-peng.The First People\'s Hospital of Yangzhou,Yangzhou 225001,China |
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| Abstract: | Objective:To investigate the effects of dexamethasone on soluble intercellular adhesion molecule-1(sICAM-1) in cerebrospinal fluid of rabbits with bacterial meningitis,Adjuvant therapy for clinical application of DEX to provide a theoretical basis for meningitis.Methods:A total of 36 rabbits were assigned to study,which were randomly divided into meningitis model group(MOD),meningitis dexamethasone-treated group(DEXT)and control group(CON).CSF was sampled for determining in different time.The concentration ... |
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| Keywords: | soluble intercellular adhesion molecule-1 meningitis cerebrospinal fluid dexamethasone |
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